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Regular use of Neem toothpaste or toothpowder and rinsing with Neem mouthwash can destroy cavity-causing bacteria, enhance the mouth’s immunity, and help prevent plaque and tartar buildup. Neem’s pain relieving compounds can help alleviate discomfort from toothaches. Apply a few drops of Neem extract on the gums near a toothache to help relieve pain and inflammation. In severe cases, consider drinking a Neem tea or taking a Neem capsule daily.